Mechanism of priming cytotoxic T cell response and strategy for enhancing DNA vaccine potency in DNA immunization / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 175-179, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-311079
ABSTRACT
DNA vaccination that can induce both cellular and humoral immune response has become an attractive immunization strategy against cancer and infectious disease. Elucidation of the precise mechanisms of immune priming will be important in the development of effective DNA vaccines. In this review, we illustrate possible mechanisms in priming cytotoxic T cell response involving the intracellular degradation, processing and presentation of encoded antigen. We also discuss the roles of costimulatory molecules expressed on antigen-presenting cells (APCs) in inducing optimal CTL activity. Hence, a rational strategy for increasing DNA potency would be to facilitate these pathways. Additionally, we focus on recent strategies including rapid degradation of ubiquitin-antigen fusion proteins, direct targeting to APCs for increased DNA uptake, direct routing an antigen into the MHC class I and II processing and presentation pathways, and increasing the immunogenicity of encoded antigen. All of these approaches have resulted in increased potency of DNA vaccines.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Linfócitos T Citotóxicos
/
Apresentação de Antígeno
/
Vacinas de DNA
/
Ubiquitina
/
Alergia e Imunologia
/
Genética
/
Lisossomos
/
Células Apresentadoras de Antígenos
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2003
Tipo de documento:
Artigo
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