Identification and Validation of Candidate Radiation-responsive Genes for Human Biodosimetr / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 834-840, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-311341
ABSTRACT
The aim of the present study is to analyze the global research trend of radiation-responsive genes and identify the highly reproducible radiation-responsive genes. Bibliometric methods were applied to analyze the global research trend of radiation-responsive genes. We found 79 publications on radiation-responsive genes from 2000 to 2017. A total of 35 highly reproducible radiation-responsive genes were identified. Most genes are involved in response to DNA damage, cell proliferation, cell cycle regulation, and DNA repair. The p53 signal pathway was the top enriched pathway. The expression levels of 18 genes in human B lymphoblastoid cell line (AHH-1) cells were significantly up-regulated in a dose-dependent manner at 24 h after exposure to 0-5 Gy 60Co γ-ray irradiation. Our results indicate that developing a gene expression panel with the 35 high reproducibility radiation-responsive genes may be necessary for qualitative and quantitative assessment after exposure.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Efeitos da Radiação
/
Radiometria
/
Regulação para Cima
/
Regulação da Expressão Gênica
/
Reprodutibilidade dos Testes
/
Perfilação da Expressão Gênica
/
Relação Dose-Resposta à Radiação
/
Métodos
Tipo de estudo:
Estudo diagnóstico
/
Pesquisa qualitativa
Limite:
Humanos
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2017
Tipo de documento:
Artigo
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