Contribution of 3CD Region to the Virulence of Enterovirus 71 / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 767-771, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-311350
ABSTRACT
Enterovirus 71 is a neuroinvasive virus that is associated with severe neurological complications. We had earlier suggested that the replication capacity of a severe strain was higher than that of a mild strain. The recombinant 3CRV and 3CDRV virus strains were successfully rescued in our previous study. In the present study, we found no difference in virulence between 3CRV and severe strains. However, the capacity of replication and to cause cell injury of 3CDRV strain decreased in vitro, especially at 39.5 °C. Replacement of 3CD region in the severe strain led to milder symptoms, less body weight loss, and lower viral load in ICR mice. Histopathological findings indicated less severe injury in mice infected with 3CDRV strain. This study suggests that the 3CD region contributes to the attenuation of the severe strain, including its replication capacity and temperature sensitivity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Proteínas Virais
/
Virologia
/
Virulência
/
Replicação Viral
/
Regulação Viral da Expressão Gênica
/
Carga Viral
/
Enterovirus Humano A
/
Efeito Citopatogênico Viral
/
Infecções por Enterovirus
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2017
Tipo de documento:
Artigo
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