Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 479-482, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-311436
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury.</p><p><b>METHODS</b>In 11 case-control study, 113 abnormal chromosome workers exposed to ionizing radiation were selected as cases and 113 normal chromosome as controls who matched with case for sex, age (+/- 5 years), nation, type of work, the same or more but in 2 years work length and the same similar levels of the cumulative exposure radiation dose. Genotypes were analysed using PCR based restriction fragment length polymorphism techniques.</p><p><b>RESULTS</b>The frequency of XRCC1 26304TT allele in case group (18.58%) was significantly higher than that in control group (7.08%), with OR for radiation damage being 3.47 (95% CI 1.43 - 8.44, P < 0.05). No association was observed between XRCC1 G27466A and G28152A and susceptibility to radiation injury.</p><p><b>CONCLUSION</b>The mutation of XRCC1 C26304T is related with the susceptibility to radiation injury. The polymorphisms of XRCC1 G27466A and G28152A are not found to have association with abnormal chromosomes.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Lesões por Radiação
/
Polimorfismo de Fragmento de Restrição
/
Estudos de Casos e Controles
/
Reação em Cadeia da Polimerase
/
Aberrações Cromossômicas
/
Predisposição Genética para Doença
/
Proteínas de Ligação a DNA
/
Reparo do DNA
/
Proteína 1 Complementadora Cruzada de Reparo de Raio-X
/
Frequência do Gene
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS