Effects and significance of gas explosion on expression of NF-kappaB and ICAM1 in lung tissue of rats / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 409-411, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-311464
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of NF-kappaB and ICAM-1 in the gas explosion wounded lung of rats and the relationship.</p><p><b>METHODS</b>Digoxin labeled NF-kappaB was used as probe. In situ hybridization was performed to detect the NF-kappaB mRNA. Immunohistochemistry was used to detect the expression of NF-kappaB and ICAM-1.</p><p><b>RESULTS</b>The levels of NF-kappaB mRNA, the expression of NF-kappaB and ICAM-1 in the wounded rats were significantly increased and reached their peak two hours after injury. Pathology of lung tissue showed that some crachea epithelium mucosae were desquamated; congestion, edema of trachea wall and infiltration of neutrophilic granulocytes were found; hemorrhage, edema and infiltration of lots of inflammatory cells were present in alveolus cells. Electron microscope showed that type I, especially type II alveolus epithelia had degeneration and desquamation.</p><p><b>CONCLUSION</b>The injury of gas explosion can activate NF-kappaB, which has close correlation with the acute injury to lung.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Traumatismos por Explosões
/
RNA Mensageiro
/
NF-kappa B
/
Ratos Sprague-Dawley
/
Molécula 1 de Adesão Intercelular
/
Explosões
/
Genética
/
Pulmão
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2006
Tipo de documento:
Artigo
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