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Antimicrobial resistance and molecular epidemiologic characteristics of Stenotrophomonas maltophilia isolated from clinical specimens
Article em Ko | WPRIM | ID: wpr-31152
Biblioteca responsável: WPRO
ABSTRACT
Sixty-eight clinical isolates of Stenotrophomonas maltophilia from inpatients of 2 university hospitals in Taegu were epidemiologically analyzed by using the minimum inhibitory concentrations of 25 antimicrobial drugs, biochemical reaction, pulsed-field gel elctropgoresis (PFGE), and PCR with enterobacterial repetitive intergenic consensus sequences as primer (ERIC-PCR). 1. All the strains were susceptible to minocycline. More than 57% were susceptible to sulfisomidine (Su), ciprofloxacin (Ci), Ofloploxacin (Of), nalidixic acid (Na), and chloramphenicol (Cm), and 19apprx35% to ceftazidime (Cd), trimethoprim (Tp), Ticacillin-clavulanic acid, and cefoperazone-sulbactam. Most isolates were resistant to beta-lactam antibiotics such as ampicillin (Ap), carbenicillin (Cb), cefotaxim (Ct), cefoxitin (Cx), and aminoglycosides including gentamicin (Gm), tobramycin (Tb), amikacin (Ak). 2. All the isolates were multiply resistant of 5 to 17 drugs and showed 40 different resistance pattern types. 3. All the strains showed very similar biochemical reactions except beta-galactosidase and nitrate reduction test. Fourteen strains selected randomly were classified 10 different pattern type by PFGE and ERIC-PCR. These two methods showed identical result. Four strains isolated from wound in 1994 showed similar MIC pattern and identical API 20NE profile, PFGE, and ERIC-PCR pattern indicating episodes of cross-infection among patients. These results indicate that PFGE or ERIC-PCR profile has comparable discriminatory power for epidemiological typing of S. maltophilia.
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Sulfisomidina / Tobramicina / Trimetoprima / Ferimentos e Lesões / Carbenicilina / Amicacina / Gentamicinas / Ciprofloxacina / Testes de Sensibilidade Microbiana / Ácido Nalidíxico Limite: Humans Idioma: Ko Revista: Journal of the Korean Society for Microbiology Ano de publicação: 2000 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Sulfisomidina / Tobramicina / Trimetoprima / Ferimentos e Lesões / Carbenicilina / Amicacina / Gentamicinas / Ciprofloxacina / Testes de Sensibilidade Microbiana / Ácido Nalidíxico Limite: Humans Idioma: Ko Revista: Journal of the Korean Society for Microbiology Ano de publicação: 2000 Tipo de documento: Article