HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1557-1560, 2003.
Artigo
em Inglês
| WPRIM
| ID: wpr-311634
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between histocompatibility leukocyte antigen (HLA)-DRB1 alleles and alveolar echinococcosis (AE).</p><p><b>METHODS</b>Thirty-five patients with AE in high prevalence areas in Gansu Province of China were tested for the HLA-DRB1 gene using the polymerase chain reaction with sequence-specific primer (PCR-SSP) technique. The results were compared with those of 104 healthy individuals.</p><p><b>RESULTS</b>The frequency of the HLA-DRB1 * 040x gene was 26% in the patient group, which was significantly higher than that in the control group (9.62%) with a relative risk (RR) of 4.45 (chi(2) = 13.67, P < 0.01), and an etiological fraction (EF) of 0.20. The frequency of the HLA-DRB1 * 0701 allele was significantly lower in the patient group (2.86%) as compared to the control group (13.94%; chi(2) = 6.67, P < 0.05) with a preventable fraction (PF) of 0.30. The frequencies of other DRB1 alleles were not significantly different.</p><p><b>CONCLUSION</b>Susceptibility to AE is significantly associated with the HLA-DRB1 * 040x. HLA-DRB1 * 0701 gene might confer protection against AE in humans.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antígenos HLA-DR
/
China
/
Epidemiologia
/
Prevalência
/
Equinococose Hepática
/
Alelos
/
Cadeias HLA-DRB1
/
Genética
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2003
Tipo de documento:
Artigo
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