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Expression of telomerase hTERT in human non-small cell lung cancer and its correlation with c-myc gene / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 1467-1470, 2003.
Artigo em Inglês | WPRIM | ID: wpr-311655
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of human telomerase catalytic subunit, hTERT, in human non-small cell lung cancer (NSCLC) and its correlations to c-myc gene.</p><p><b>METHODS</b>hTERT and c-myc mRNA expressions were detected by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Statistical correlation analysis was made to estimate whether there was interrelation between them.</p><p><b>RESULTS</b>Positive rate of hTERT expression in 51 surgically resected lung cancer specimens was 86.3%, significantly higher than that in adjacent non-neoplastic lung tissues and benign lesions, which were 14.3% and 27.3% respectively. No statistical significance was observed between the frequency of hTERT expression and histologic types, degree of differentiation, TNM stages, tumor size or lymph nodes metastases. Correlation analysis revealed that the expression of c-myc gene was significantly related to that of hTERT (correlation coefficient, r = 0.633, P < 0.001).</p><p><b>CONCLUSIONS</b>hTERT may be a useful tumor marker in diagnosing lung cancer. Significant correlation between the expression of hTERT and c-myc mRNA indicates that the activation and up-regulation of hTERT might be conferred by over-expression of c-myc gene.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Carcinoma de Células Escamosas / Adenocarcinoma / Biomarcadores Tumorais / Genes myc / Carcinoma Adenoescamoso / Carcinoma Pulmonar de Células não Pequenas / Telomerase / Reação em Cadeia da Polimerase Via Transcriptase Reversa / Proteínas de Ligação a DNA Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Carcinoma de Células Escamosas / Adenocarcinoma / Biomarcadores Tumorais / Genes myc / Carcinoma Adenoescamoso / Carcinoma Pulmonar de Células não Pequenas / Telomerase / Reação em Cadeia da Polimerase Via Transcriptase Reversa / Proteínas de Ligação a DNA Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2003 Tipo de documento: Artigo