Advances in the research of rheological behavior of platelets and its regulation after burn / 中华烧伤杂志

ABSTRACT

Microcirculatory dysfunction of local wounds and distant tissues after burns results in ischemia and hypoxia of tissues and organs, thus affecting the course and prognosis of burns. Platelet is an important component of blood, and the changes in its rheological behavior influence the blood flow in the microcirculation, as well as the microvascular structure and function. The abnormality of platelet rheological behavior plays an important role in the occurrence and development of microcirculatory dysfunction after burn. Changes in rheological behavior of platelets are due to changes in platelet morphology, adhesion, aggregation, shrinkage functions, and release reaction. Investigation of platelet rheological behavior and its regulation after burn may be of significant implication in the analysis of patient's condition and instruction for treatment. This article reviews the changes in platelet rheological behavior and its regulation after burn in the aspects of morphology, adhesion, aggregation, shrinkage functions, and release reaction.