Structures and pharmacological activities of beesiosides O and P / 药学学报
Acta Pharmaceutica Sinica
;
(12): 788-792, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-312048
ABSTRACT
<p><b>AIM</b>To investigate the chemical constituents of the rhizomes of Beesia calthaefolia native to China in order to obtain a more comprehensive understanding of its effective components.</p><p><b>METHODS</b>Compounds were isolated by column chromatography with silica gel. Their structures were elucidated by spectral analysis and chemical evidence. Compounds identified were subjected to pharmacological evaluation.</p><p><b>RESULTS</b>Two novel compounds were isolated and identified as (20S, 24S)-15 alpha-acetoxy-16 beta, 24; 20, 24-diepoxy-9, 19-cyclolanostane-3 beta, 25-diol-3-O-beta-D-xylopyranoside (I) and (20S, 24R)-15 alpha-acetoxy-9, 19-cyclolanostane-3 beta, 16 beta, 20, 24, 25-pentaol-3-O-beta-D-xylopyranoside (II), named beesioside O and beesioside P.</p><p><b>CONCLUSION</b>Compounds I and II are new compounds. Compounds I exhibited immunosuppressive activity and could inhibit angiogenesis as well as inhibit the proliferation of osteoblast. Compound II displayed remarkable inhibition activity against calcium channel receptor.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Saponinas
/
Bloqueadores dos Canais de Cálcio
/
Estrutura Molecular
/
Química
/
Inibidores da Angiogênese
/
Ranunculaceae
/
Imunossupressores
/
Conformação Molecular
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2002
Tipo de documento:
Artigo
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