The enhancing effect of electroporation and iontophoresis on the permeation of insulin through human skin / 药学学报
Acta Pharmaceutica Sinica
;
(12): 649-652, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-312061
ABSTRACT
<p><b>AIM</b>To study the enhancing effect of electroporation and iontophoresis on the permeation of insulin through human cadaver skin in vitro.</p><p><b>METHODS</b>Using side by side two-chamber diffusion cells, the flux of insulin achieved with iontophoresis and electrophoration were compared.</p><p><b>RESULTS</b>The application of high-voltage pulse combined with iontophoresis resulted in higher flux transdermal permeation of insulin than either one technique alone (P < 0.05). Pulsing at a higher voltage increased the flux of insulin more dramatically than pulsing at a lower voltage (P < 0.01). The transdermal transport of insulin by 90 pulse of 500 V (exponential pulse generater, pulse time 20-24 ms, pulse frequency 3 pulse.min-1) followed by iontophoresis led to a quick input and a high steady flux.</p><p><b>CONCLUSION</b>Electroporation combined with iontophoresis can enhance the permeation of insulin significantly.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Permeabilidade
/
Pele
/
Absorção Cutânea
/
Técnicas In Vitro
/
Farmacocinética
/
Iontoforese
/
Eletroporação
/
Insulina
/
Metabolismo
/
Métodos
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2002
Tipo de documento:
Artigo
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