An analysis of blinding success in a randomised controlled trial of fish oil omega-3 fatty acids
Annals of the Academy of Medicine, Singapore
;
: 85-91, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-312197
ABSTRACT
<p><b>INTRODUCTION</b>Incidental reports collected in clinical trials suggest that amongst participants, omega-3 fatty acids derived from fish oil ('omega-3') may be difficult to blind.</p><p><b>MATERIALS AND METHODS</b>We conducted a systematic evaluation of blinding success in a 24-week trial of omega-3 versus an oil-based placebo. Within 1 week of supplement commencement (Week 1), a blinding questionnaire was completed by 131 children enrolled in a trial of omega-3 for the treatment of disruptive behaviour disorders. A version of the questionnaire was also completed by their parents at Week 1, and by the children at the end of supplement administration (Week 24).</p><p><b>RESULTS</b>Participants were unable to differentiate omega-3 from placebo, and accuracy did not improve as a function of the confidence of guesses, reason for guesses, notice of any change, beliefs about what should change, or time. Child and parent guesses also showed high concordance.</p><p><b>CONCLUSION</b>Taken together, these data provide strong evidence that the identity of omega-3 can be blinded to participants.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pais
/
Ácidos Graxos Ômega-3
/
Método Simples-Cego
/
Inquéritos e Questionários
/
Transtornos de Deficit da Atenção e do Comportamento Disruptivo
/
Suplementos Nutricionais
/
Usos Terapêuticos
/
Dietoterapia
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Annals of the Academy of Medicine, Singapore
Ano de publicação:
2015
Tipo de documento:
Artigo
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