An analysis of blinding success in a randomised controlled trial of fish oil omega-3 fatty acids
Annals of the Academy of Medicine, Singapore
; : 85-91, 2015.
Article
em En
| WPRIM
| ID: wpr-312197
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>INTRODUCTION</b>Incidental reports collected in clinical trials suggest that amongst participants, omega-3 fatty acids derived from fish oil ('omega-3') may be difficult to blind.</p><p><b>MATERIALS AND METHODS</b>We conducted a systematic evaluation of blinding success in a 24-week trial of omega-3 versus an oil-based placebo. Within 1 week of supplement commencement (Week 1), a blinding questionnaire was completed by 131 children enrolled in a trial of omega-3 for the treatment of disruptive behaviour disorders. A version of the questionnaire was also completed by their parents at Week 1, and by the children at the end of supplement administration (Week 24).</p><p><b>RESULTS</b>Participants were unable to differentiate omega-3 from placebo, and accuracy did not improve as a function of: the confidence of guesses, reason for guesses, notice of any change, beliefs about what should change, or time. Child and parent guesses also showed high concordance.</p><p><b>CONCLUSION</b>Taken together, these data provide strong evidence that the identity of omega-3 can be blinded to participants.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pais
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Ácidos Graxos Ômega-3
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Método Simples-Cego
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Inquéritos e Questionários
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Transtornos de Deficit da Atenção e do Comportamento Disruptivo
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Suplementos Nutricionais
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Usos Terapêuticos
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Dietoterapia
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Annals of the Academy of Medicine, Singapore
Ano de publicação:
2015
Tipo de documento:
Article