Expression of hMLH1 in rectal intraepithelial neoplasm and early rectal carcinoma / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 1162-1165, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-312327
ABSTRACT
<p><b>OBJECTIVE</b>To explore whether the abnormality of hMLH1 gene may be an early event of carcinogenesis in rectal carcinoma, and to evaluate the diagnostic value in differentiation between intraepithelial neoplasm and early stage of colorectal carcinoma.</p><p><b>METHODS</b>The expression of hMLH1 protein in 28 cases with early invasive rectal carcinoma(EIRC), 36 cases with rectal intraepithelial neoplasm(RIEN), and 30 cases with normal rectal mucosa(NRM) which were collected through surgical operations were detected by PV-9000 immunohistochemical method.</p><p><b>RESULTS</b>The positive expression rates of hMLH1 protein were 100%(30/30), 77.8%(28/36), and 39.3%(11/28) in NRM, RIEN, and EIRC respectively. The difference was statistically significant between RIEN and EIRC(P=0.002), and the difference was also statistically significant between RIEN and NRM(P=0.006). The positive expression of hMLH1 was not related to age, gender, tumor maximum diameter, dysplasia, tumor types, and distance from the anal verge in RIEV group(P>0.05). In EIRC group, hMLH1 was associated with tumor differentiation(P<0.05).</p><p><b>CONCLUSION</b>hMLH1 gene deletion may be an early event during carcinogenesis of rectal carcinoma, which may be useful in differentiation of intraepithelial neoplasm from early rectal carcinoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Retais
/
Proteínas Nucleares
/
Carcinoma in Situ
/
Proteínas Adaptadoras de Transdução de Sinal
/
Diagnóstico
/
Detecção Precoce de Câncer
/
Proteína 1 Homóloga a MutL
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2012
Tipo de documento:
Artigo
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