Antipyretic and anticonvulsant activity of n-hexane fraction of Viola betonicifolia
Asian Pacific Journal of Tropical Biomedicine
;
(12): 280-283, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-312415
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the antipyretic and anticonvulsant activities of n-hexane fraction of Viola betonicifolia (V. betonicifolia).</p><p><b>METHODS</b>The antipyretic effect was scrutinized using brewer's yeast induced pyrexia and anticonvlsion effect was tested using pentylenetetrazol and strychnine induced convulsion in mice.</p><p><b>RESULTS</b>N-hexane fraction of V. betonicifolia demonstrated highly significant antipyretic activity during various assessment times (1-5 h) when challenged in yeast induced pyrexia test. The effect was in a dose dependent manner with maximum attenuation (82.50%) observed at 300 mg/kg i.p. When tested in pentylenetetrazol induced convulsion test, the 1st stage (Ear and facial twitching) and 2nd stage (Convulsive wave through the body) was 100% protected during 24 h at all the test doses (300, 400 and 500 mg/kg i.p.), while the latency time of remaining stages was significantly increased. The maximum effect was observed by n-hexane fraction of V. betonicifolia at 400 and 500 mg/kg i.p., as the latency time for generalized clonic-tonic seizure (5th stage) was increased up to 25.34 min. However, n-hexane fraction of V. betonicifolia had no protection in strychnine induced convulsion test.</p><p><b>CONCLUSIONS</b>In conclusion, phytopharmacological studies provide scientific foundation to the folk uses of the plant in the treatment of pyrexia and neurological disorders.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Convulsões
/
Extratos Vegetais
/
Química
/
Viola
/
Modelos Animais de Doenças
/
Tratamento Farmacológico
/
Antipiréticos
/
Febre
/
Hexanos
Limite:
Animais
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Biomedicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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