Association between HSD11B2 gene polymorphism and fetal growth / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1286-1290, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-312587
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between HSD11B2 polymorphisms and fetal growth during normal pregnancy.</p><p><b>METHODS</b>The HSD11B2 promoter/G-209A, G-194C, G-151A and G-126A genotypes were examined in 33 samples from Chinese Han subjects by gene sequencing. HSD11B2 (CA)n microsatellite polymorphism in the first intron was detected in blood samples from 187 maternal and newborn pairs by PCR-capillary electrophoresis.</p><p><b>RESULTS</b>All the HSD11B2 promoter/G-209A, G-194C, G-151A and G-126A genotypes were wild-type GG. The offspring birth weight and any ultrasound parameters describing late gestational fetal body shape were not significantly different between maternal or fetal SS, SL and LL groups or combined SS+SL and LL groups. When considering the relevant confounding factors (gestational age at delivery, newborn's gender, maternal body mass index before pregnancy, maternal weight at delivery and maternal age), the offspring birth weight and late pregnancy ultrasound parameters were still not associated with the maternal or fetal HSD11B2 (CA) n microsatellite polymorphisms.</p><p><b>CONCLUSIONS</b>Fetal and maternal HSD11B2 polymorphism is not related to fetal growth during normal pregnancy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Peso ao Nascer
/
Índice de Massa Corporal
/
Idade Gestacional
/
Regiões Promotoras Genéticas
/
11-beta-Hidroxiesteroide Desidrogenase Tipo 2
/
Desenvolvimento Fetal
/
Genética
/
Genótipo
Limite:
Feminino
/
Humanos
/
Recém-Nascido
/
Gravidez
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2014
Tipo de documento:
Artigo
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