Resting-state brain functional magnetic resonance imaging in patients with type 2 diabetes mellitus / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1083-1091, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-312631
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate early occult brain functional damage in patients with type 2 diabetes mellitus using resting-state functional magnetic resonance imaging (MRI).</p><p><b>METHODS</b>High-resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MRI and resting-state functional MRI images were obtained from 18 patients with type 2 diabetes mellitus and 18 normal control subjects. Regional homogeneity (ReHo) map, amplitude of low-frequency fluctuation (ALFF) map, and functional connectivity map of the bilateral hippocampus and posterior cingulate gyrus were calculated and voxel-based analysis was performed using two-sample t-test.</p><p><b>RESULTS</b>In type 2 diabetic patients, decreased ReHo was deteted in the right thalamus, hippocampus, olfactory cortex and left putamen as compared with the normal controls. The decreased ALFF was found mainly in the left middle frontal gyrus, right supramarginal gyrus and middle occipital gyrus in the diabetic patients. The patients showed reduced functional connectivity between the bilateral hippocampus but not between the bilateral posterior gyrus and the other brain regions.</p><p><b>CONCLUSION</b>The occult brain damage is featured by decreased ReHo and ALFF in multiple brain regions and reduced functional connectivity between the bilateral hippocampus in type 2 diabetic patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Encéfalo
/
Lesões Encefálicas
/
Mapeamento Encefálico
/
Imageamento por Ressonância Magnética
/
Estudos de Casos e Controles
/
Imageamento Tridimensional
/
Diabetes Mellitus Tipo 2
/
Lobo Frontal
/
Giro do Cíngulo
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2014
Tipo de documento:
Artigo
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