Intraoperative methylene blue and (99m)Tc-sulfur colloid isotope tracing for sentinel node mapping in early-stage non-small cell lung cancer / 南方医科大学学报
Journal of Southern Medical University
; (12): 1053-1056, 2014.
Article
em Zh
| WPRIM
| ID: wpr-312639
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the accuracy of intaoperative methylene blue alone and in combination with (99m)Tc-sulfur colloid isotopic tracing for detection of sentinel lymph nodes (SLNs) in early-stage non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>Sixty-one patients with operable NSCLC who did not receive previous radiotherapy or chemotherapy were enrolled. Methylene blue and (99m)Tc-sulfur colloid were injected into the subserosal layer adjacent to the tumor, and SLNs were defined as those with blue staining or those containing 3 times more radioactivity than the surrounding tissue detected with a gamma probe. The SLN were removed with systematic lymph node dissection. All the removed lymph nodes were examined histopathologically with HE staining and immunohistochemistry.</p><p><b>RESULTS</b>Methylene blue alone showed a low detection rate (60.0%) and sensitivity (58.33%) for SLNs compared with the combination of methylene blue and isotope tracing (96.15% and 92.86%, respectively).</p><p><b>CONCLUSION</b>The combination of methylene blue and (99m)Tc-sulfur colloid isotopic tracing allows accurate detection of the SLNs in early-stage NSCLC.</p>
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1
Índice:
WPRIM
Assunto principal:
Patologia
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Enxofre
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Coloide de Enxofre Marcado com Tecnécio Tc 99m
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Imuno-Histoquímica
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Coloides
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Carcinoma Pulmonar de Células não Pequenas
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Biópsia de Linfonodo Sentinela
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Diagnóstico
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Isótopos
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Excisão de Linfonodo
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2014
Tipo de documento:
Article