Effects of propofol on pulmonary metastasis of intravenous injected tumor cells and expressions of MTA1 and Wnt1 in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1011-1015, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-312648
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of different doses of propofol on pulmonary metastasis of intravenous injected tumor cells and expression of MTA1 and Wnt1 in the metastatic tumor in rats.</p><p><b>METHODS</b>Forty male Fischer344 rats were randomly divided into 4 equal groups for intravenous administration of normal saline, intralipid, or propofol at the dose of 30 or 50 mg/kg pumped via the femoral vein. One hour after the infusion, MADB106 tumor cells (2×10) were injected intravenously in the rats. Pulmonary metastasis of the tumor cells was observed and the expression of MTA1 and Wnt1 in the metastatic tumor detected by immunohistochemistry 3 weeks later.</p><p><b>RESULTS</b>The rats receiving saline and intralipid treatments showed a comparable number of pulmonary metastasis and similar expression levels of MTA1 and Wnt1 in the metastatic tumor (P>0.05); the tumor number and MTA1 and Wnt1 were significantly lower in the two propofol groups (P<0.01). The doses of propofol was inversely correlated with the number of pulmonary metastasis (r=-0.879) and expressions of MTA1 (r=-0.980) and Wnt1 (r=-0.916) (P<0.01), and MTA1 and Wnt1 expression levels in the metastatic tumors were closed correlated (r=0.902, P<0.01).</p><p><b>CONCLUSION</b>Propofol can dose-dependently suppress pulmonary metastasis of intravenously injected tumor cells and down-regulate MTA1 and Wnt1 expressions in the metastatic tumor tissue.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Ratos Endogâmicos F344
/
Imuno-Histoquímica
/
Proteínas
/
Propofol
/
Proteína Wnt1
/
Genética
/
Injeções Intravenosas
/
Neoplasias Pulmonares
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2014
Tipo de documento:
Artigo
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