Effect of integrated Chinese medical treatment (as maintenance therapy) on the survival time of patients with advanced non-small-cell lung cancer: a clinical study / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 526-530, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-312784
ABSTRACT
<p><b>OBJECTIVE</b>To observe clinical effect of integrated Chinese medical (CM) treatment (as maintenance therapy) on the progression-free survival (PFS) and overall survival (OS) in patients with advanced non-small-cell lung cancer (NSCLC) after first-line chemotherapy.</p><p><b>METHODS</b>The study was a prospective, randomized, controlled clinical trial. Totally 69 non-progressive advanced NSCLC patients treated with first-line chemotherapy were randomly assigned to the test group (34 cases) and the control group (35 cases). Patients in the control group were treated with one Western drug chemotherapy (Gemcitabine or Alimta or docetaxel). Those in the test group were treated with integrated CM treatment (CM decoction, CM Intravenous preparation, and point application). Each cycle consisted of 21 days. Treatment lasted till the disease progressed, or intolerable toxic/adverse reactions occurred, or patients refused to continue the treatment. Patients' life spans were regularly followed-up.</p><p><b>RESULTS</b>(1) The median cycle of maintenance therapy was 2 cycles for two groups with no statistical difference (P =0.274). The median PFS was 12.43 weeks in the test group and 10.00 weeks in the control group, showing statistical difference (P =0.025). The middle survival time (MST) was 18.8 months in the test group and 16.73 months in the control group, showing no statistical difference (P =0.437).</p><p><b>CONCLUSION</b>CM treatment (as maintenance therapy) showed quail effect to one Western drug chemotherapy in prolonging patients' life span.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medicamentos de Ervas Chinesas
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Estudos Prospectivos
/
Carcinoma Pulmonar de Células não Pequenas
/
Intervalo Livre de Doença
/
Taxoides
/
Usos Terapêuticos
/
Desoxicitidina
/
Tratamento Farmacológico
/
Pemetrexede
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2014
Tipo de documento:
Artigo
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