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Effect of ru'ai shuhou recipe on immune response in HER2/neu tranagenic mice undergoing breast cancer carcinogenesis process / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 717-756, 2010.
Artigo em Chinês | WPRIM | ID: wpr-313214
ABSTRACT
<p><b>OBJECTIVE</b>To explore the immune response induced by HER2/neu oncogene in the breast cancer (BC) carcinogenesis process and the immunological mechanism of Ru'ai Shuhou Recipe (RSR) in the prevention and treatment of BC.</p><p><b>METHODS</b>HER2/neu transgenic spontaneous breast tumor model mice were fed with RSR from 5 weeks old, the occurrence of breast tumor in them was observed, and the changes of T cell-mediated immune response and associated cytokines were detected during the carcinogenesis process, i. e., when mice aged between 15 and 25 weeks.</p><p><b>RESULTS</b>RSR showed significant effects in postponing and reducing the carcinogenesis of primary breast tumor, up-regulating the amount of T cell in splenic lymphocyte in tumor-bearing mice, promoting the proliferation of T lymphocyte, and inducing the secretion of cytokines such as interleukin-2, interleukin-12 and interferon-y.</p><p><b>CONCLUSIONS</b>A serial immune response reveals in the carcinogenesis process. The immunologic function of HER-2/neu transgenic mice is significantly different to that of the same strain non-transgenic mice. Effect of RSR in preventing and postponing breast cancer carcinogenesis is possibly realized through enhancing the anti-tumor immune response of transgenic mice themselves.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Baço / Neoplasias da Mama / Medicamentos de Ervas Chinesas / Camundongos Transgênicos / Linfócitos T / Receptor ErbB-2 / Genes erbB-2 / Biologia Celular / Proliferação de Células Limite: Animais Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Baço / Neoplasias da Mama / Medicamentos de Ervas Chinesas / Camundongos Transgênicos / Linfócitos T / Receptor ErbB-2 / Genes erbB-2 / Biologia Celular / Proliferação de Células Limite: Animais Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2010 Tipo de documento: Artigo