Effect of ru'ai shuhou recipe on immune response in HER2/neu tranagenic mice undergoing breast cancer carcinogenesis process / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 717-756, 2010.
Article
em Zh
| WPRIM
| ID: wpr-313214
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the immune response induced by HER2/neu oncogene in the breast cancer (BC) carcinogenesis process and the immunological mechanism of Ru'ai Shuhou Recipe (RSR) in the prevention and treatment of BC.</p><p><b>METHODS</b>HER2/neu transgenic spontaneous breast tumor model mice were fed with RSR from 5 weeks old, the occurrence of breast tumor in them was observed, and the changes of T cell-mediated immune response and associated cytokines were detected during the carcinogenesis process, i. e., when mice aged between 15 and 25 weeks.</p><p><b>RESULTS</b>RSR showed significant effects in postponing and reducing the carcinogenesis of primary breast tumor, up-regulating the amount of T cell in splenic lymphocyte in tumor-bearing mice, promoting the proliferation of T lymphocyte, and inducing the secretion of cytokines such as interleukin-2, interleukin-12 and interferon-y.</p><p><b>CONCLUSIONS</b>A serial immune response reveals in the carcinogenesis process. The immunologic function of HER-2/neu transgenic mice is significantly different to that of the same strain non-transgenic mice. Effect of RSR in preventing and postponing breast cancer carcinogenesis is possibly realized through enhancing the anti-tumor immune response of transgenic mice themselves.</p>
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Índice:
WPRIM
Assunto principal:
Farmacologia
/
Baço
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Neoplasias da Mama
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Medicamentos de Ervas Chinesas
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Camundongos Transgênicos
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Linfócitos T
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Receptor ErbB-2
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Genes erbB-2
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Biologia Celular
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Proliferação de Células
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2010
Tipo de documento:
Article