Comparison of immunological profiles between pediatric and adult patients with AIDS in China / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 647-650, 2006.
Article
em Zh
| WPRIM
| ID: wpr-313715
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the immunological profiles of pediatric and adult patients with AIDS in China.</p><p><b>METHODS</b>Totally 103 pediatric AIDS patients, 38 adult patients, 88 healthy children, and 72 healthy adults were enrolled. CD4 + T lymphocyte counts were determined by four-color flow cytometer and HIV-RNA levels were measured in EDTA plasma by quantitative reverse-transcription polymerase chain reaction (RT-PCR). Plasma levels of interleukin (IL)-10, IL-16, IL-18, regulated upon activation, normal T-cell expressed and secreted (RANTES), monocyte chemoattractant protein 1 (MCP-1), stromal cell-derived factor-(SDF-1) alpha, SDF-1 beta, and macrophage stimulate protein (MSP) were quantified by enzyme-linked immunosorbent assay (ELISA). The levels of beta 2-microglobulin (beta 2-MG) and soluble Fas (sFas) were measured to indicate the activation of immune system.</p><p><b>RESULTS</b>The mean CD4 + T cell count in pediatric patients with AIDS was significantly lower than in healthy children (P < 0.01), as between the adult AIDS patients and healthy adults (P < 0.01). The mean levels of these cytokines in pediatric patients were significantly higher than in healthy children (P < 0.01). The level of MSP in adult patients was significantly lower than in healthy adults and other cytokines were significantly higher (P < 0.01). The mean levels of these cytokines, except SDF1 alpha and beta 2-MG, were significantly higher in pediatric patients than in adult patients (P < 0.01).</p><p><b>CONCLUSION</b>Abnormal immune activation is induced in both pediatric and adult patients with HIV-1 infection. The level of immune activation is higher in pediatric patients than in adult patients.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Sangue
/
Ativação Linfocitária
/
Fatores Quimiotáticos
/
Proteínas Proto-Oncogênicas
/
Síndrome da Imunodeficiência Adquirida
/
Interleucinas
/
Fator de Crescimento de Hepatócito
/
Contagem de Linfócito CD4
/
Alergia e Imunologia
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2006
Tipo de documento:
Article