Pathology of AIDS-related lymphadenopathy and its relationship to expression of CD4 + CD25 + regulatory T cells in lymphoid node tissue / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 622-625, 2006.
Article
em Zh
| WPRIM
| ID: wpr-313720
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the pathology of AIDS-related lymphadenopathy and its relationship to the expression and distribution of CD4 + CD25 + regulatory T cells in lymphoid node tissue.</p><p><b>METHODS</b>Totally 22 biopsy and 13 autopsy lymphoid node tissues from HIV-positive patients were examined under microscopy and pathological staging was performed. Specific marker for CD4 + CD25 + regulatory T cells in lymphoid node tissue was detected with anti-Foxp3 monoclonal antibody by immunohistochemistry.</p><p><b>RESULTS</b>Among all the 35 specimens, 5, 4, 14, and 12 specimens were histopathologically staged from 1 to 4, respectively. FoxP3 were detected in all lymphoid node tissues. The distribution of FoxP3-positive lymphocytes were mainly in intermediate zone of follicle and cortical area in stages 1 and 2. The counts of FoxP3-positive lymphocytes remarkably decreased in stages 3 and 4, following depletion of lymphocytes.</p><p><b>CONCLUSIONS</b>CD4 + CD25 + regulatory T cells exist in lymphoid node tissue of patients with HIV infection. Their amounts decrease or deplete along with the progression of AIDS-related lymphadenopathy.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Imuno-Histoquímica
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Síndrome da Imunodeficiência Adquirida
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Linfócitos T Reguladores
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Contagem de Linfócito CD4
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Alergia e Imunologia
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Fatores de Transcrição Forkhead
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Linfonodos
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Doenças Linfáticas
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Metabolismo
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2006
Tipo de documento:
Article