Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 46-49, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-314087
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Yangqixue Qufengshi Recipe (YQXQFS) on rheumatoid arthritis (RA) model mice under different genetic backgrounds.</p><p><b>METHODS</b>Collagen Induced Arthritis (CIA) were established on HLA-DR4 transgenic (TG) mice and non-transgenic (NTG) mice, which partly were raised with YQXQFS, and the onset day of CIA, the level of type II collagen (CII)-reactive antibodies and the pathological scores of CIA were assessed.</p><p><b>RESULTS</b>Under HLA-DR4 TG background (compared with NTG mice), the earlier onset day of CIA (11.22 +/- 3.35 days vs 16.56 +/- 4.75 days, P < 0.05) and higher level of CII-reactive antibodies (0.2274 +/- 0.1390 microg/ml vs 0.1101 +/- 0.0560 microg/ml, P < 0.05) were observed, but the pathological scores of CIA remained unchanged. YQXQFS could not influence the onset day of CIA and the level of CII-reactive antibodies, but had a certain effect on the total pathological scores (6.56 +/- 3.43 scores vs 11.11 +/- 5.64 scores) and bone erosion (0.22 +/- 0.44 scores vs 1.67 +/- 1.50 scores) of CIA on NTG mice (P < 0.05), NTG YQXQFS group compared with NTG experimental group.</p><p><b>CONCLUSION</b>YQXQFS had a certain effect on RA model, but had no significant effect on HLA-DR4 related CIA.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Artrite Experimental
/
Artrite Reumatoide
/
Sangue
/
Medicamentos de Ervas Chinesas
/
Antígeno HLA-DR4
/
Camundongos Knockout
/
Antirreumáticos
/
Colágeno Tipo II
/
Usos Terapêuticos
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese journal of integrative medicine
Ano de publicação:
2006
Tipo de documento:
Artigo
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