Common variable immunodeficiency: report of two cases and literature review / 中华血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To promote the awareness of common variable immunodeficiency (CVID).</p><p><b>METHODS</b>Report two cases of CVID and review related literature.</p><p><b>RESULTS</b>The two CVID patients were manifested recurrent infections of respiratory and digestive tract, splenomegaly, significantly reduced serum immunoglobulin, since adolescence. They were treated with intravenous gammaglobulin, anti-infection and symptomatic therapies and the diseases were well controlled. Case 1 was diagnosed as with spleen peripheral T cell lymphoma after splenectomy. Case 2 developed nutritional megaloblastic anemia resulting from repeated digestive tract infections.</p><p><b>CONCLUSION</b>CVID is a heterogeneous group of diseases with later-onset, characterized by hypogammaglobulinemia and recurrent bacterial infections. Early diagnosis and regular treatment may improve the prognosis.</p>