Chemical constituents from stems of Brucea mollis and their cytotoxic activity / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2321-2324, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-315033
ABSTRACT
Ten compounds were isolated from the stems of Brucea mollis by various chromatographic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as deacetylated isobrucein B (1), indaquassin X (2), cleomiscosin A (3), cleomiscosin B (4), (+)-lyoniresinol (5), (+)-epipinoresinol(6), (+)-pinoresinol (7), (+)-syringaresinol (8), 4,5-dihydroblumenol A (9) and adenosine (10) on the basis of spectroscopic data analysiS. All compounds were obtained from this plant for the first time, moreover, compound 1 was a new natural product. Compound 2 showed significant cytotoxic activities against the human cell lines HT-29, HepG2, BGC-823 and SKOV3 with IC50 values of 0.84-3.97 micromol x L(-1).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Extratos Vegetais
/
Química
/
Caules de Planta
/
Células HT29
/
Concentração Inibidora 50
/
Brucea
/
Linhagem Celular Tumoral
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2013
Tipo de documento:
Artigo
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