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Clinical study on treatment of recurrent genital herpes by Huangqi Fuzheng Decoction / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 222-224, 2008.
Artigo em Chinês | WPRIM | ID: wpr-315162
ABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical efficacy of Huangqi Fuzheng Decoction (HQFZD) in treating recurrent genital herpes (RGH) and its influence on related cytokines in peripheral blood.</p><p><b>METHODS</b>Eighty-four patients with RGH were randomly assigned to 3 groups, the treated group treated with HQFZD (31 cases), the control group A (25 cases) treated with Aciclovir, and the control group B (28 cases) treated with Aciclovir plus interferon. The course of treatment was 3 weeks for all. The relapse rate was estimated at 6 months after treatment, and levels of IL-4, IL-10, IL-12 and IL-18 in all patients were detected before and after treatment using double-sandwich ELISA.</p><p><b>RESULTS</b>All patients were cured after treatment. The relapse rate in the treated group and the control group B was lower than that in the control group A (P < 0.01) but insignificant difference was shown between the former two groups. Before treatment, patients' serum levels of IL-4 and IL-10 were significantly higher while those of IL-12 and IL-18 were lower than the normal range (P < 0.01). The abnormal change aforementioned reversed after treatment in the treated group and the control group B (P < 0.05 or P < 0.01), showing a superior effect to that in the control group A (P < 0.01).</p><p><b>CONCLUSION</b>HQFZD can reduce the relapse rate of RGH without obvious adverse reaction, and it could also enhance the immunity of the patients.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Recidiva / Sangue / Medicamentos de Ervas Chinesas / Herpes Genital / Citocinas / Interleucina-4 / Interleucina-10 / Interleucina-12 / Interleucina-18 Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Recidiva / Sangue / Medicamentos de Ervas Chinesas / Herpes Genital / Citocinas / Interleucina-4 / Interleucina-10 / Interleucina-12 / Interleucina-18 Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2008 Tipo de documento: Artigo