Effects of 3 genosides on bio-thermodynamic expression of splenic lymphocyte in mice / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 54-57, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-315181
ABSTRACT
<p><b>OBJECTIVE</b>To establish a new method for screening active ingredients of Chinese herbs by determining different bio-thermodynamic effects of 3 genosides on splenic lymphocyte of mice.</p><p><b>METHODS</b>Using a thermal bioactivity monitoring system, the maximum heat output (mHO), average metabolic heat (MH) and constant of decrease rate (DR) of lymphocyte were determined based on the growth metabolic power-time curve, and the outcomes were verified by MIT.</p><p><b>RESULTS</b>The mHO and MH increased and the DR decreased after lymphocytes being exposed to the 3 genosides in different concentrations, arranged upon their potency as genoside Rg3 > genoside Rg2 > genoside Rg1 (merely insignificant effect). MTT showed the same results.</p><p><b>CONCLUSION</b>Heat activity monitoring system could precisely display the different bio-thermal dynamic effects of 3 genosides on splenic lymphocyte.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Baço
/
Termodinâmica
/
Linfócitos
/
Sobrevivência Celular
/
Células Cultivadas
/
Biologia Celular
/
Ginsenosídeos
/
Metabolismo Energético
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo
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