Constituents from Alternanthera philoxeroides and their antitumor activity / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2473-2476, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-315419
ABSTRACT
<p><b>OBJECTIVE</b>To investigate antitumor constituents from n-butyl alcohol extract of Alternanthera philoxeroides.</p><p><b>METHOD</b>The constituents were isolated with silica gel, gel permeation chromatography, and purified by HPLC. Their structures were elucidated by spectroscopy and acid hydrolysis. The antitumor effects of extracts and isolated compounds were tested by MTH method in vitro.</p><p><b>RESULT</b>Seven compounds were isolated and elucidated as followings oleanolic acid 3-O-beta-D-glucuronopyranoside (1), oleanolic acid 28-O-beta-D-glucopyranoside (2), oleanolic acid 3-O-beta-D-glucuronopyranoside-6'-O-methyl ester (3), chikusetsusaponin IV a methyl ester (4), hederagenin 3-O-beta-D-glucuronopyranoside-6'-O-methyl ester (5), 4,5-dihydroblumenol (6), 6S,7E,9R-6,9-di-hydroxymegastigma-4,7-dien-3-one-9-O-beta-D-glucopyranoside (7). Compound 1 showed significant inhibitory effect against Hela and L929 with inhibitive ratios 91.3% and 92.9% at 30 mg x L(-1), respectively.</p><p><b>CONCLUSION</b>Compounds 4, 5 and 7 were isolated from this genus for the first time. Compound 1 showed significant inhibitory effect against Hela and L929 at 30 mg x L(-1).</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Química
/
Amaranthaceae
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Hidrólise
/
Antineoplásicos
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Artigo
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