Slow anti-epileptic drug taper protocol in video-EEG monitoring for presurgical evaluation of epilepsy / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1197-1200, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-315503
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of slow anti-epileptic drug (AED) taper protocol and a rescue benzodiazepine protocol in video-electroencephalography (video-EEG) monitoring for presurgical evaluation of epilepsy.</p><p><b>METHODS</b>Sixty-two of 109 patients with refractory focal epilepsy underwent pre-surgical video-EEG monitoring with a slow AEDs taper protocol and a rescue benzodiazepine protocol. Seizures were recorded by video-EEG in 56 patients. The time to the first seizure, duration of monitoring, incidence of 4-h and 24-h seizure clustering, secondarily generalized tonic-clonic seizures (sGTCS), status epilepticus, falls and cardiac asystole were evaluated.</p><p><b>RESULTS</b>A total of 191 seizures were recorded in the 56 cases, and the diagnostic efficiency of video-EEG was 90.3%. The mean time to the first seizure was 2.4 days and the time to conclude video-EEG monitoring averaged 6.8 days. Eight (12.9%) patients had 4-h clusters and 24 (38.7%) had 24-h clusters. Seizure clusters were more frequent in extra temporal epilepsy than in temporal lobe epilepsy. While 19 sGTCS were recorded in 15 patients (26.8%), status epilepticus did not occur and no seizure was complicated by cardiac asystole. Epileptic falls with no significant injuries occurred in 4 patients.</p><p><b>CONCLUSION</b>Seizure clustering is common during presurgical video-EEG monitoring, but serious adverse events are rare with a slow AED tapering and a rescue benzodiazepine protocols. These two protocols are effective and save in presurgical video-EEG monitoring for refractory focal epilepsy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndrome de Abstinência a Substâncias
/
Gravação em Vídeo
/
Usos Terapêuticos
/
Diagnóstico
/
Tratamento Farmacológico
/
Eletroencefalografia
/
Epilepsia
/
Métodos
/
Monitorização Fisiológica
/
Anticonvulsivantes
Tipo de estudo:
Estudo diagnóstico
/
Guia de Prática Clínica
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2012
Tipo de documento:
Artigo
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