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Association of serum transforming growth factor-β1 with radiation injury and survival of patients with early-stage nasopharyngeal carcinoma / 南方医科大学学报
Journal of Southern Medical University ; (12): 1171-1174, 2012.
Artigo em Chinês | WPRIM | ID: wpr-315510
ABSTRACT
<p><b>OBJECTIVE</b>To observe the changes in serum transforming growth factor-β1 (TGF-β1) in patients with early-stage nasopharyngeal carcinoma (NPC) after radiotherapy and explore the correlation of serum TGF-β1 with radiation injury and disease-free survival.</p><p><b>METHODS</b>The average serum TGF-β1 level (50.2∓3.2 ng/ml) determined from 32 healthy volunteers was used as the standard value for NPC patients in this trial. Fifty-seven patients with early-stage (T1-2N0-1M0) NPC without prior treatment were divided into two groups with serum TGF-β1 level before treatment lower than or equal to the standard value (group A, 29 cases) and a level beyond the standard value (group B, 28 cases). Serum TGF-β1 level was determined in all the patients before, during and after the radiotherapy to evaluate the radiation injury and therapeutic effect.</p><p><b>RESULTS</b>The serum TGF-β1 level before radiotherapy was significantly lower in group A than in group B (35.4∓1.4 vs 58.8∓1.0 ng/ml, P<0.05). After radiotherapy, acute radiation mucositis and skin reaction was significantly severer in group B (P<0.05). The serum TGF-β1 level before radiotherapy was significantly higher in patients with grade 3 acute radiation mucositis and skin reaction than in those with injuries below grade 3 (54.0∓2.2 vs 42.0∓2.3 ng/ml and 54.3∓2.4 vs 43.4∓2.2 ng/ml, P<0.05). The two groups showed no significant differences in the locoregional failure rate (3.4% vs 7.1%), distant metastasis rate (3.4% vs 10.8%) or disease-free survival (P>0.05).</p><p><b>CONCLUSIONS</b>Radiotherapy can significantly decrease serum TGF-β1 level in early NPC patients. Serum TGF-β1 level before radiotherapy can help predict the degree of acute radiation mucositis and skin reaction, but shows no correlation with disease-free survival of early-stage NPC patients.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Lesões por Radiação / Radioterapia / Sangue / Carcinoma / Estudos de Casos e Controles / Neoplasias Nasofaríngeas / Taxa de Sobrevida / Mortalidade / Fator de Crescimento Transformador beta1 Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Lesões por Radiação / Radioterapia / Sangue / Carcinoma / Estudos de Casos e Controles / Neoplasias Nasofaríngeas / Taxa de Sobrevida / Mortalidade / Fator de Crescimento Transformador beta1 Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2012 Tipo de documento: Artigo