Analysis of association between the IRF5 gene single nucleotide polymorphism and allergic rhinitis / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
;
(12): 22-25, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-315827
ABSTRACT
<p><b>OBJECTIVE</b>To study the possible association between interferon regulatory factor 5 (IRF5) gene polymorphism and allergic rhinitis (AR).</p><p><b>METHODS</b>Six independent single nucleotide polymorphism (SNP, rs729302, rs4728142, rs3807306, rs2070197, rs11770589, rs2280714) were analyzed. The genotype and allele frequencies were detected in 110 AR patients and 101 healthy controls in Singapore Chinese population by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).</p><p><b>RESULTS</b>Rs729302 was rejected as it was not polymorphic. For others SNP, no statistically significant difference was detected in genotype between AR and healthy control group (χ(2) value were 0.21, 5.02, 0.01, 2.91, 0.37, all P > 0.05). No statistically significant difference was detected in allele frequencies between AR and healthy control group (χ(2) value were 0.00, 2.78, 0.01, 2.31, 0.00, all P > 0.05).</p><p><b>CONCLUSION</b>No association is observed between IRF5 and AR in Singapore Chinese population.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Singapura
/
Estudos de Casos e Controles
/
Rinite Alérgica Perene
/
Polimorfismo de Nucleotídeo Único
/
Fatores Reguladores de Interferon
/
Rinite Alérgica
/
Frequência do Gene
/
Genética
/
Genótipo
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2013
Tipo de documento:
Artigo
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