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Effects and mechanisms of shaoqiduogan on mice with chemical liver injury / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1807-1810, 2006.
Artigo em Chinês | WPRIM | ID: wpr-315951
ABSTRACT
<p><b>OBJECTIVE</b>To study the therapeutic effects and mechanisms of SQDG on carbon tetrachloride-induced chemical liver injury in mice as well as its possible mechanisms. At the same time the pharmacodynamics of SQDG was compared with TGP or ASTs of effective dose.</p><p><b>METHOD</b>The model of carbon tetrachloride-induced chemical liver injury in mice was prepared. The levels of ALT, AST, MDA content, SOD and GSH-Px activities in liver homogenate were assayed by spectrophotometry; Meanwhile, hepatic pathological examination was observed.</p><p><b>RESULT</b>Protective effect of SQDG on carbon tetrachloride-induced chemical liver injury SQDG was able to significantly decrease serum transaminase levels of chemical liver injury's mice induced by carbon tetrachloride, decreased MDA content and improved the reduced SOD and GSH-px levels in liver homogenate. Furthermore, SQDG also attenuate the area and extent of necrosis and reduce the infiltration of inflammatory cell. Compared with TGP or ASTs of effective dose, SQDG has a better effect on carbon tetrachloride-induced chemical liver injury in mice.</p><p><b>CONCLUSION</b>SQDG can protect mice injured by carbon tetrachloride-induced chemical.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Plantas Medicinais / Aspartato Aminotransferases / Superóxido Dismutase / Sangue / Intoxicação por Tetracloreto de Carbono / Química / Substâncias Protetoras / Astragalus propinquus Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Plantas Medicinais / Aspartato Aminotransferases / Superóxido Dismutase / Sangue / Intoxicação por Tetracloreto de Carbono / Química / Substâncias Protetoras / Astragalus propinquus Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2006 Tipo de documento: Artigo