Studies on diterpenoids from Andrographis paniculata / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the diterpenoids in the 85% ethanol extract of the aerial parts of Andrographis paniculata.</p><p><b>METHOD</b>Fourteen diterpenoids from the 85% EtOH extract were isolated by the silica gel, Sephadex LH-20, ODS column chromatography and HPLC, and their structures were identified by the spectal analyses and chemical evidences.</p><p><b>RESULT</b>The 14 compounds were obtained and identified as neoandrographolide (1), 3, 14-di-deoxyandrographolide (2), andrographolide (3), 14-deoxy-11, 12-didehydroandrographolide (4), 19-hydroxy-8 (17), 13-labdadien-15, 16-olide (5), 14-deoxy-andrographolide (6), 3-oxo-14-deoxy-andrographolide (7), isoandrographolide, (8), bisandrographolide (9, 10, 11), deoxyandrographiside (12), 14-deoxy-11, 12-didehydroandrographiside (13), andrographiside (14), respectively.</p><p><b>CONCLUSION</b>Compound 7 was a new natural product, and compound 5 was obtained for the first time from the Andrographis species.</p>