Study on antitumor activities of huanglian jiedu decoction / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1461-1463, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-316022
ABSTRACT
<p><b>OBJECTIVE</b>To study the antitumor activity of Huanglian Jiedu decoction (HLJDT).</p><p><b>METHOD</b>Antitumor activities were tested in mice with experimental tumor H22 in vivo, and the thymus index, spleen index and tumor inhibitory rate were evaluated. The effects on cancer cells from human were investigated in vitro using serum pharmacological approach. Swille, SPC-A-1, SGC-7901 and MCF-7 cancer cells were incubated in culture media containing serum from mice medicated with HLJDT. The inhibitory effects of HLJDT serum were observed by MTT assay.</p><p><b>RESULT</b>HLJDT showed significant antitumor activities on H22 in mice. All of the HLJDT serum in different dosage groups could highly inhibit the proliferation of 4 cancer cell lines from human.</p><p><b>CONCLUSION</b>The HLJDT can significantly inhibit the tumor H22 in mice in a dose-dependent manner, the drug serum has obvious anticancer effects against Swille, SPC-A-1, SGC-7901 and MCF-7.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Plantas Medicinais
/
Timo
/
Medicamentos de Ervas Chinesas
/
Química
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Relação Dose-Resposta a Droga
/
Combinação de Medicamentos
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2006
Tipo de documento:
Artigo
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