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Effects of xuezhikang and simvastatin on cerebral ischemia-reperfusion injury in rat / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1447-1450, 2006.
Artigo em Chinês | WPRIM | ID: wpr-316026
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of Xuezhikang and simvastatin on cerebral ischemia/reperfusion injury in rat, as well as the influences after intervention with L-NAME.</p><p><b>METHOD</b>Rats were given orally with Xuezhikang and simvastatin or vehicle for 2 weeks, and then subjected to middle cerebral artery occlusion for 120 min using intraluminal filament model. L-NAME were injected into the lateral ventricles in half of the rats treated with Xuezhikang and simvastatin 45 min before the ischemia. The neurological deficits examinations were performed at 2, 24, 48 h after reperfusion. After the last examination the animals were sacrificed, the infarct volumes were determined by TTC staining, and MDA levels were also measured.</p><p><b>RESULT</b>Xuezhikang and simvastatin both significantly reduced the infarct volume and improved the functional recovery when compared to vehicle. Xuezhikang and simvastatin both significantly decreased the MDA accumulation after reperfusion. L-NAME partially inhibited the protective effect of Xuezhikang but nearly completely abolished the protective effect of simvastatin.</p><p><b>CONCLUSION</b>Xuezhikang has protective effects on ischemic brain damage in rats, which the beneficial effects are partly due to the statins components. The other components in Xuezhikang may also account for the neuroprotective effects, which is worth further investigations.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Encéfalo / Medicamentos de Ervas Chinesas / Traumatismo por Reperfusão / Isquemia Encefálica / Ratos Sprague-Dawley / Fármacos Neuroprotetores / NG-Nitroarginina Metil Éster / Sinvastatina Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Encéfalo / Medicamentos de Ervas Chinesas / Traumatismo por Reperfusão / Isquemia Encefálica / Ratos Sprague-Dawley / Fármacos Neuroprotetores / NG-Nitroarginina Metil Éster / Sinvastatina Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2006 Tipo de documento: Artigo