Phase I study of docetaxel combined with carboplatin in patients with non-small cell lung cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 946-948, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-316260
ABSTRACT
<p><b>OBJECTIVE</b>To determine the maximum tolerated dose (MTU) and dose-limiting toxicity (DLT) of Docetaxel and Carboplatin in patients with non-small cell lung cancer.</p><p><b>METHODS</b>Docetaxel was given at escalating doses until MTD was determined from the initial dose of 65 mg/m2 to 75 mg/m2, 85 mg/ m2 on dl. Carboplatin was targeted to an area under the plasma concentration curve of 5 using Calver's equation on dl. The treatment cycle was repeated every 3 weeks.</p><p><b>RESULTS</b>16 patients received TXT and CBP for total of 54 courses (median four courses). Neutropenia was the dose-limiting toxicity. The MTD of TXT is 85 mg/m2.</p><p><b>CONCLUSION</b>We recommend TXT 75 mg/m2 on d1 and CBP with a target AUC of 5 on d1, 3weeks repeated for chemotherapy in naïve patients with NSCLC.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Indução de Remissão
/
Esquema de Medicação
/
Protocolos de Quimioterapia Combinada Antineoplásica
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Carboplatina
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Carcinoma Pulmonar de Células não Pequenas
/
Taxoides
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Neoplasias Pulmonares
/
Neutropenia
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2006
Tipo de documento:
Artigo
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