A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 670-673, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-316330
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between sulfotransferase 1Al polymorphism, diet and colorectal cancer susceptibility.</p><p><b>METHODS</b>A case-control study of 140 cancers and 343 health controls was conducted to investigate the role of sulfotransferase 1A1 polymorphism and meat consumption in colorectal carcinogenesis. Genotypes of sulfotransferase 1A1 polymorphism were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).</p><p><b>RESULTS</b>There was no significant difference in allele frequency of SULT1A1 between the control and cancer patient populations. After adjustment for age, sex, smoking and history of diseases, red meat and well-done meat intake showed no significant association with colorectal cancer. Consumption of red meat more than 5 kg per year combined with SULT1Al slow sulfation (Arg/His and His/His) had a statistically significant association with the risk of rectal cancer ( OR = 3.78; 95% CI 1.08 - 13. 20) compared to that consumed red meat less than 5 kg per year with fast sulfation (Arg/Arg).</p><p><b>CONCLUSION</b>This study suggests that SULT1A1 slow sulfation combined with higher intake of red meat may be associated with an elevated risk of rectal cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Neoplasias Retais
/
Suínos
/
Arilsulfotransferase
/
Fumar
/
Estudos de Casos e Controles
/
Fatores de Risco
/
Neoplasias do Colo
/
Predisposição Genética para Doença
/
Dieta
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2006
Tipo de documento:
Artigo
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