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Separation and identification of cis and trans isomers of 2-butene-1,4-diol and lafutidine by HPLC and LC-MS / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B ; (12): 74-78, 2005.
Artigo em Inglês | WPRIM | ID: wpr-316373
ABSTRACT
The cis and trans isomers separation of 2-butene-1,4-diol and lafutidine were studied by HPLC on two kinds of chiral columns (S,S)-Whelk-O 1 and ChiraSpher. The isomers of 2-butene-1,4-diol can be separated on both chiral columns while the isomers of lafutidine can only be resolved on ChiraSpher column. The influence of different type and amount of mobile phase modifier on the isomers separation was extensively studied. The resolution of cis and trans isomers of 2-butene-1,4-diol was 2.61 on (S,S)-Whelk-O 1 column with hexane-ethanol (973, v/v) as the mobile phase. The resolution of lafutidine was 1.89 on ChiraSpher column with hexane-ethanol-THF-diethylamine (92350.1, v/v/v/v) as the mobile phase. LC-MS methods were developed to identify the isomer peaks.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Piperidinas / Piridinas / Espectrometria de Massas / Butileno Glicóis / Química / Cromatografia Líquida de Alta Pressão / Fracionamento Químico / Isomerismo / Acetamidas / Métodos Idioma: Inglês Revista: Journal of Zhejiang University. Science. B Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Piperidinas / Piridinas / Espectrometria de Massas / Butileno Glicóis / Química / Cromatografia Líquida de Alta Pressão / Fracionamento Químico / Isomerismo / Acetamidas / Métodos Idioma: Inglês Revista: Journal of Zhejiang University. Science. B Ano de publicação: 2005 Tipo de documento: Artigo