Impact of loop diuretics on blood sodium in patients hospitalized for heart failure / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 582-587, 2014.
Article
em Zh
| WPRIM
| ID: wpr-316407
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the level of blood sodium in patients hospitalized for heart failure with water-sodium retention treated with loop diuretics and risk factors of low blood sodium.</p><p><b>METHODS</b>We selected 1 378 acute decompensated heart failure patients who visited Anzhen Hospital, and they are treated with loop diuretics, 259 patients with weight loses more than 1 kg in one week was enrolled in the final analysis, and divided into 3 groups: Group A (weight reduction between 1-3 kg), Group B (weight reduction between 3-5 kg) and Group C (weight reduction over 5 kg). Blood sodium, creatinine and uric acid were compared among groups and risk factors of low blood sodium were analyzed.</p><p><b>RESULTS</b>Blood sodium was similar before and post loop diuretics treatment in Group A, and reduced in group B ((138.28 ± 3.73) mmol/L vs. (139.34 ± 3.66) mmol/L, P < 0.05) and in Group C((137.60 ± 4.07) mmol/L vs. (139.44 ± 4.12) mmol/L, P < 0.05). Forty-six (17.8%) patients developed hyponatremia post loop diuretics treatment. Duration of loop diuretics use was the independent risk infector for hyponatremia (OR = 1.191, 95%CI 1.010-1.385).</p><p><b>CONCLUSIONS</b>Loop diuretics use is safe for treating hospitalized patients for heart failure with water-sodium retention and the risk of developing hyponatremia is low. Duration of loop diuretics use is the independent risk factor of hyponatremia.</p>
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1
Índice:
WPRIM
Assunto principal:
Sódio
/
Sangue
/
Sódio na Dieta
/
Doença Aguda
/
Fatores de Risco
/
Creatinina
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Inibidores de Simportadores de Cloreto de Sódio e Potássio
/
Insuficiência Cardíaca
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2014
Tipo de documento:
Article