Single-agent maintenance therapy in non-small cell lung cancer: a systematic review and meta-analysis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 3143-3149, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-316553
ABSTRACT
<p><b>BACKGROUND</b>Can single-agent maintenance therapy be considered as an ideal strategy for non-small cell lung cancer (NSCLC) treatment to achieve prolonged survival and tolerated toxicity? A systematic review and meta-analysis was performed to elucidate this issue.</p><p><b>METHODS</b>The electronic databases were searched for RCTs comparing single-agent maintenance therapy with placebo, best support care or observation. The required data for estimation of response, survival and toxicity were extracted from the publications and the combined data were calculated.</p><p><b>RESULTS</b>Eleven RCTs involving 3686 patients were identified. We found a statistically significant higher probability of tumor response for patients with maintenance therapy versus control patients (OR 2.80, 95%CI 2.15 - 3.64). Patients receiving maintenance therapy had significantly longer progression-free survival (PFS) (HR 0.67, 95%CI 0.62 - 0.71) and overall survival (OS) (HR 0.84, 95%CI 0.78 - 0.90). However, maintenance therapy was associated with more severe toxicities (OR 6.45, 95%CI 4.61 - 9.01).</p><p><b>CONCLUSION</b>In patients with advanced NSCLC, the use of single-agent maintenance therapy is associated with higher response rate and significantly prolongs PFS and OS despite of the risk of additional toxicity.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Mortalidade
/
Viés de Publicação
/
Carcinoma Pulmonar de Células não Pequenas
/
Intervalo Livre de Doença
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Neoplasias Pulmonares
/
Antineoplásicos
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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