Association between single-nucleotide polymorphisms in the IRAK-4 gene and allergic rhinitis / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
;
(12): 476-480, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-316635
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the genetic association pattern between single-nucleotide polymorphisms (SNP) in the interleukin-1 receptor-associated kinase 4 (IRAK-4) gene and allergic rhinitis (AR).</p><p><b>METHODS</b>A population of 379 patients with the diagnosis of AR and 333 healthy controls who lived in Beijing region was recruited. A total of 8 reprehensive marker SNP which were in IRAK-4 gene region were selected according to the Beijing people database from Hapmap website. The individual genotyping was performed by MassARRAY platform. SPSS 13.0 software was used for statistic analysis.</p><p><b>RESULTS</b>Subgroup analysis for the presence of different allergen sensitivities displayed associations only in the house dust mite-allergic cohorts (rs3794262 P = 0.0034, OR = 1.7388; rs4251481 P = 0.0023, OR = 2.6593), but not in subjects who were allergic to pollens as well as mix allergens.</p><p><b>CONCLUSION</b>The potential genetic contribution of the IRAK-4 gene to AR demonstrated an allergen-dependant association pattern in Chinese population.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Alérgenos
/
Estudos de Casos e Controles
/
Rinite Alérgica Perene
/
Rinite Alérgica Sazonal
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Alergia e Imunologia
/
Quinases Associadas a Receptores de Interleucina-1
/
Genética
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2012
Tipo de documento:
Artigo
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