Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen / 中华创伤杂志(英文版)

ABSTRACT

<p><b>PURPOSE</b>To develop a novel injectable strontium-containing calcium phosphate cement with collagen.</p><p><b>METHODS</b>A novel calcium phosphate bone cement (CPC) was prepared with the addition of strontium element, collagenl, and modified starch; the injectability, solidification time, microstructure, phase composition, compressive strength, anti-collapsibility and histological properties of material were evaluated.</p><p><b>RESULTS</b>The results showed that the material could be injected with an excellent performance; the modified starch significantly improved the anti-washout property of cement; with the liquid to solid ratio of 0.3, the largest compressive strength of cement was obtained (48.0 MPa ± 2.3 MPa); histological examination of repair tissue showed that the bone was repaired after 16 weeks; the degradation of cement was consistent with the new bone growth.</p><p><b>CONCLUSION</b>A novel injectable collagen-strontium-containing CPC with excellent compressive strength and suitable setting time was prepared, with addition of modified starch. The CPC showed a good anti-washout property and the degradation time of the cement met with the new bone growing. This material is supposed to be used in orthopedic and maxillofacial surgery for bone defects.</p>