Research of the relationship of ubiquinone and beclin-1 and liver mitochondria / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 250-252, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-318051
ABSTRACT
<p><b>OBJECTIVE</b>To study whether CO-Q10 can protect liver injury caused by acute on chronic liver failure (ACLF) by autophagy.</p><p><b>METHODS</b>Rats were separated into three groups control group, acute on chronic liver failure (ACLF) and intervenient group, liver tissues were observed by optical microscopy and electron microscopy. The levels of Beclin-1 expression were determined by real-time PCR. And Western Blot.</p><p><b>RESULTS</b>Areas of necrosis detected in intervenient group were alleviated than in ACLF significantly. Most mitochondrias had been degradated in ACLF group while alive in intervenient group. Real-time PCR and Western Blot revealed level of beclin-1 in ACLF was lower than control and intervenient group.</p><p><b>CONCLUSION</b>Intervenient group may ameliorate rat liver injury by promoting autophagy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Autofagia
/
Mitocôndrias Hepáticas
/
Ubiquinona
/
Ratos Sprague-Dawley
/
Falência Hepática Aguda
/
Proteínas Reguladoras de Apoptose
/
Proteína Beclina-1
/
Genética
/
Metabolismo
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2013
Tipo de documento:
Artigo
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