Dynamic analysis of the lymphocyte subsets in HCV children with different genotypes during treatment / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 204-206, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-318064
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the changes of lymphocyte subsets in HCV children with different genotypes during treatment with pegylated interferon alfa-2b and ribavirin.</p><p><b>METHODS</b>The genotype of 45 HCV infected children were identified by real time PCR. The lymphocyte subsets were dynamically detected by BD FACSCalibur flow cytometer with four color MultiTEST IMK Kit during the treatment.</p><p><b>RESULTS</b>For the children with 1b genotype, after 24 weeks, the CD4+ T cells were higher than pre-treatment (P < 0.05). For the children with 2a genotype, after 12 weeks and after 24 weeks, the CD3+ T cells and CD4+ T cells significantly increased while the NK cells decreased than pre-treatment (P < 0.05).</p><p><b>CONCLUSIONS</b>The lymphocyte subsets of HCV children with 2a genotype were different from 1b genotype during trentment with pegylated interferon alfa-2b and ribavirin.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Virologia
/
RNA Viral
/
Estudos Retrospectivos
/
Subpopulações de Linfócitos
/
Classificação
/
Hepacivirus
/
Hepatite C Crônica
/
Tratamento Farmacológico
/
Alergia e Imunologia
/
Genética
Tipo de estudo:
Estudo observacional
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2013
Tipo de documento:
Artigo
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