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Study on absorption location of four components from Naoxintong capsule / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 889-893, 2013.
Artigo em Chinês | WPRIM | ID: wpr-318622
ABSTRACT
<p><b>OBJECTIVE</b>To study the absorption characteristics of four components from Naoxintong capsule in intestines.</p><p><b>METHOD</b>In vitro everted gut sac method was adopted for preparing the intestinal absorption solution of Naoxintong capsule. UPLC was used to detect the content of chemical components in different intestinal segments, and comparing the results with the absorption of chemical components of Naoxintong capsule in each intestinal segment. The time-accumulative absorption curve was drawn to observe the changes in the accumulative absorption concentration with time.</p><p><b>RESULT</b>Four ingredients of Naoxintong capsule can be detected in intestinal absorption solution, they are ferulic acid, paeoniflorin, salvianolic acid B and hydroxysafflor yellow A. Specifically, the accumulative absorption concentrations of ferulic acid, salvianolic acid B and paeoniflorin in ileum and rear jejunum segments were higher than that in front and middle jejunum segments; the absorption of ferulic acid, paeoniflorin, salvianolic acid B and hydroxysafflor yellow A did not reach saturated conditions in 3 hours.</p><p><b>CONCLUSION</b>Ferulic acid, paeoniflorin, salvianolic acid B and hydroxysafflor yellow A are absorbed in the whole intestine. Ferulic acid, paeoniflorin and salvianolic acid B may be absorbed in specific segments.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cápsulas / Medicamentos de Ervas Chinesas / Química / Reprodutibilidade dos Testes / Ratos Sprague-Dawley / Absorção Intestinal / Metabolismo Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cápsulas / Medicamentos de Ervas Chinesas / Química / Reprodutibilidade dos Testes / Ratos Sprague-Dawley / Absorção Intestinal / Metabolismo Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2013 Tipo de documento: Artigo