A new flavanol glycoside from Phymatopteris hastata with effect on glucose metabolism / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 831-834, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-318635
ABSTRACT
By repeated column chromatography, including silica gel, macroporous resin, and preparative HPLC, a new compound (1) was isolated and purified. On the basis of spectroscopic methods, the structure of 1 was elucidated as ( - ) -epiafzelechin-3, 5-di-O-beta-D-apiofuranoside (1). In the bioassay screening experiments, glucose consumption assays in IR HepG2 cells and colorimetric assay of surface GLUT4myc translocation were used to assess the effects on glucose metabolism of compound 1. Both compound 1 and its derivatives--naringin could improve glucose consumption in IR HepG2 cells and enhance GLUT4 translocation in skeletal muscle cell L6myc in a dose-dependent manner, indicating that these two compouds showed potential anti-diabetic activities in vitro.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Catequina
/
Química
/
Transporte Proteico
/
Polypodiaceae
/
Relação Dose-Resposta a Droga
/
Transportador de Glucose Tipo 4
/
Células Hep G2
/
Glucose
/
Glicosídeos
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS