Osteoclasts take part in modulation for bone marrow hematopoietic microenvironment--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1312-1316, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-318732
ABSTRACT
Bone marrow hematopoietic microenvironment occupies the medullary cavities of bones throughout the skeleton and provides support for hematopoiesis and immune cells development. Bone-resorbing osteoclasts in bone marrow environment are specialized cells derived from the hematopoietic stem cells and play a pivotal role in process termed as bone remodeling that involves break down and build-up of bone. It is only recently that studies have provided a novel basis for understanding potential role of osteoclasts in homeostasis, stress-induced mobilization of hematopoietic progenitors and osteoimmunology. Further exploration on the interaction of osteoclasts with others in bone marrow hematopoietic microenvironment may contribute to future clinical treatments for hematopoietic and bone-related immunologic disorders including cancer. In this review the origin and identification of osteoclasts and regulation of mobilizing hematopoietic stem cells, as well as osteoclasts and osteoimmunity were mainly concerned.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoclastos
/
Fisiologia
/
Células da Medula Óssea
/
Células-Tronco Hematopoéticas
/
Remodelação Óssea
/
Biologia Celular
/
Alergia e Imunologia
/
Hematopoese
/
Homeostase
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2007
Tipo de documento:
Artigo
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