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Aberrant immunophenotypes in 126 patients with acute leukemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1032-1036, 2007.
Artigo em Chinês | WPRIM | ID: wpr-318795
ABSTRACT
The existence of leukemia aberrant immunophenotypes (LAIP) has been suggested to be a valuable tool for the detection of minimal residual disease (MRD), as they could distinguish leukemic cells from normal hematopoietic progenitors. This study was purposed to analyze the characteristics of LAIP in acute leukemia and further explore the proportion of different types of LAIP in acute leukemia patients. Flow cytometry (FCM) with four color and CD45/SSC gating were used to detect the antigen expression in samples of bone marrow from 126 patients with acute leukemia. The results showed that definite LAIP could be detected in about 76% patients. The LAIP could be divided into four groups as cross-lineage antigen expression, asynchronous antigen expression, antigen overexpression and antigen lack expression. The percentages of these LAIPs were 39%, 46%, 21% and 29% respectively. About 11% out of analyzed cases showed the existence of only one aberrant phenotype while two or more of aberrant phenotypes could be detected in majority cases. It is concluded that the LAIP with four subgroups can be detected in the majority of patients with acute leukemia and immunophenotyping based on LAIP is applicable for the detection of MRD.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Leucemia / Doença Aguda / Imunofenotipagem / Antígenos Comuns de Leucócito / Neoplasia Residual / Diagnóstico / Alergia e Imunologia / Citometria de Fluxo / Anticorpos Monoclonais Tipo de estudo: Estudo diagnóstico Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Leucemia / Doença Aguda / Imunofenotipagem / Antígenos Comuns de Leucócito / Neoplasia Residual / Diagnóstico / Alergia e Imunologia / Citometria de Fluxo / Anticorpos Monoclonais Tipo de estudo: Estudo diagnóstico Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2007 Tipo de documento: Artigo