Repair of peripheral nerve gap with the use of tissue engineering scaffold complex / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 688-691, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-318836
ABSTRACT
<p><b>OBJECTIVE</b>To study the feasibility to repair the peripheral nerve gap with tissue engineering scaffold complex that is composed of medical biodegradable material agarose hydrogel and nerve growth factor (NGF).</p><p><b>METHODS</b>Chitosan tube containing agarose hydrogel and NGF was transplanted to bridge a 10 mm gap of injured sciatic nerve in rat. Chitosan duct without agarose hydrogel and NGF was used as negative control, while autograft nerve as positive control. Sixteen weeks after operation, the regeneration of nerve fiber was observed with morphological and immunohistochemistrical methods.</p><p><b>RESULT</b>The number and diameter of regenerating nerve fibers bridged by the scaffold complex of agarose hydrogel and NGF were better than negative control group (P < 0.01) and reached the level of autograft nerve group.</p><p><b>CONCLUSIONS</b>The new type of tissue engineering scaffold complex of agarose hydrogel and NGF may provide a microenvironment, as well as autograft nerve, to promote nerve regeneration. This technique may benefit patients with nerve injury in the future.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Nervos Periféricos
/
Farmacologia
/
Sefarose
/
Cirurgia Geral
/
Materiais Biocompatíveis
/
Stents
/
Estudos de Viabilidade
/
Ratos Sprague-Dawley
/
Implantação de Prótese
/
Hidrogel de Polietilenoglicol-Dimetacrilato
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2005
Tipo de documento:
Artigo
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