Intrarenal artery injection of L-arginine inhibits spontaneous activity of renal afferent nerve fibers / 生理学报
Acta Physiologica Sinica
;
(6): 225-231, 2003.
Artigo
em Inglês
| WPRIM
| ID: wpr-318912
ABSTRACT
The purpose of this study was to determine the effect of intrarenal artery injection of L-arginine on multi- and single-unit spontaneous discharges of renal afferent nerve fibers in anesthetized rabbits. The results obtained are as follows (1) intrarenal artery injection of L-arginine (0.05, 0.24, and 0.48 mmol/kg) decreased the renal afferent nerve activity (ARNA) in a dose-dependent manner with arterial pressure unchanged; (2) pretreatment with a nitric oxide synthase inhibitor L-NAME (N6-nitro-L-arginine methylester, 0.11 mmol/kg), completely abolished the effect of L-arginine; and (3) intrarenal artery injection of a nitric oxide donor SIN-1 (3-morpholinosydnonimine, 3.75 micromol/kg) also resulted in an inhibition of ARNA. The results suggest that intrarenal artery injection of NO precursor (L-arginine) and donor (SIN-1) can inhibit ARNA in anesthetized rabbits.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Arginina
/
Fisiologia
/
Artéria Renal
/
Fibras Aferentes Viscerais
/
Depressão Química
/
Fenômenos Eletrofisiológicos
/
Injeções Intra-Arteriais
/
Rim
/
Fibras Nervosas
Limite:
Animais
Idioma:
Inglês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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